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Hugh Arthur Pritchard Memorial Lecture for Graduate Students on Jan. 10

The Department of Pharmacology at the University of Maryland School of Medicine invites you to join us as P. Jeffrey Conn, PhD, the Lee E. Limbird Professor of Pharmacology and director of the Vanderbilt Center for Neuroscience Drug Discovery at Vanderbilt University, presents the 5th Hugh Arthur Pritchard Memorial Lecture for Graduate Students.

The lecture is titled “Positive Allosteric Modulators of GPCRs as a Novel Treatment for Schizophrenia” and will be held Thursday, Jan. 10, at 3 p.m. in the Health Science Research Facility II Auditorium, with a reception to follow.

Previous clinical studies as well as a large number of cellular and animal behavioral studies suggest that selective activators of M1 and/or M4 subtypes of muscarinic acetylcholine receptors (mAChRs) could provide a novel approach to treatment of schizophrenia. Especially exciting is the possibility that such agents could have efficacy in treatment of positive, negative, and cognitive symptoms in schizophrenia patients. Unfortunately, previous efforts to develop selective agonists of individual mAChR subtypes have not been successful and previous compounds have failed in development because of adverse effects due to activation of multiple mAChR subtypes.

Furthermore, the relative roles of M1 and M4 in mediating the overall therapeutic effects of less-selective mACh agonists are not understood. We have developed highly selective positive allosteric modulators (PAMs) of both M1 and M4 that have excellent properties for in vivo studies and as drug candidates. Electrophysiology and genetic studies are providing important new insights into the mechanisms by which M1 and M4 PAMs act in specific cortical and midbrain circuits that are relevant for treatment of different symptom domains in schizophrenia patients. Interestingly, selective M1 PAMs have specific effects in forebrain circuits that are relevant for cognitive deficits and negative symptoms and have robust efficacy in animal models of these symptom domains. In contrast, selective M4 PAMs have novel cellular actions in the basal ganglia relevant for positive symptoms and have robust antipsychotic-like effects in animal models. Also we have now advanced highly optimized M1 and M4 PAMs into preclinical and clinical development to evaluate their potential utility in treatment of schizophrenia.

More recently, we have built on recent human genetic studies that implicate two specific subtypes of metabotropic glutamate (mGlu) receptors, mGlu1 and mGlu3, in schizophrenia. Optimized mGlu1 and mGlu3 PAMs were used along with mouse genetic studies to evaluate the roles of these receptors in specific basal ganglia and forebrain circuits that have been implicated in schizophrenia. These studies are providing exciting new evidence that highly selective activators of these two glutamate receptors have potential utility in treatment of positive (mGlu1), negative (mGlu1), and cognitive (mGlu3) symptoms of schizophrenia patients. Furthermore, the novel mGlu1 and mGlu3 PAMs discovered in these studies provide excellent drug leads for further optimization and ultimate clinical testing. Collectively, these studies are providing insights that could lead to exciting new approaches for treatment of multiple symptom clusters in schizophrenia patients.

Shalon EdwardsBulletin Board, Research, UMB NewsDecember 11, 20180 comments
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The President's Message - December 2018

The President’s Message

Check out the December issue of The President’s Message. It includes Dr. Perman’s column on our record-shattering year in extramural funding — $667.4 million in grants and contracts. Also, a holiday greeting; TEDx UMB showcases our big ideas; ceremonial opening for HSRF III; Project Feast serves Thanksgiving meals to those in need; Nursing, Social Work win HEED awards for diversity; students prevail in national public health interprofessional challenge; informatics pioneer saluted at UMB; University takes the fight against opioid addiction on the road; be merry, and wary, around the holidays; and a roundup of student, faculty, and staff achievements.

Back issues of the newsletter can be found in the archives.
Chris ZangABAE, Bulletin Board, Clinical Care, Collaboration, Community Service, Contests, Education, For B'more, People, Research, UMB News, University Life, USGADecember 10, 20180 comments
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"Bloodsworth" Book Discussion

One Maryland One Book Discussion: ‘Bloodsworth’

Please join UMB’s Council for the Arts & Culture and the Thurgood Marshall Law Library for a discussion of the One Maryland One Book program’s selected book, Bloodsworth: The True Story of the First Death Row Inmate Exonerated by DNA Evidence, by Tim Junkin.

Read the book ahead of time and join us for a discussion Jan. 16 at noon in Room 3314 in the Thurgood Marshall Law Library.

Drinks and light refreshments will be provided. Feel free to bring your lunch.

Michele OndraBulletin Board, People, University LifeDecember 4, 20180 comments
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University of Maryland School of Medicine and Center for Vaccine Development and Global Health logo

Female Research Volunteers Needed for Cytomegalovirus Vaccine Study

The Center for Vaccine Development and Global Health (CVD) at the School of Medicine is recruiting healthy females for a study on human cytomegalovirus (CMV). To learn more, go to this webpage.

You may be eligible if you are:

  • A female
  • 16 to 35 years old
  • In good health
  • Have exposure to young children

Participation lasts about three years. You will receive three investigational vaccinations. You will be compensated for your time and transportation. For more information, call 410-706-6156 between 8 a.m. and 4 p.m.

Human CMV also is known as human herpesvirus 5 (HHV-5). Contracting CMV appears to require close or intimate contact with persons who are releasing CMV in their urine, saliva, or other secretions. CMV also can be transmitted via blood transfusion, breast milk, sexual intercourse, and transplanted organs.

In most healthy individuals, CMV infection is symptom-free. When symptoms are present, they are often mild, can be confused with other illnesses, and include fever, sore throat, fatigue, and/or swollen glands. After infection, the virus remains in the body. Healthy individuals with latent CMV infection can reactivate to shed the virus in their saliva or urine, which also is predominantly symptom-free. It is known that CMV can cause serious disease in newborns who are exposed during the pregnancy and in immuno-compromised individuals. The range of disease in newborns with CMV infection includes fetal/infant death to neurological and sensory impairments, which are diagnosed later in childhood.

Linda WadsworthBulletin Board, ResearchDecember 3, 20180 comments
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Human finger while it pushes the blue register online button on aluminium computer keyboard on office desk.

Spring Semester Parking Registration for Students

Attention, student parkers at UMB:

Spring semester online parking registration begins Jan. 1, and new and returning parkers must register online. After Feb. 8, posted garage rates will apply to all students who have not purchased or renewed their permit and garage access will be denied.

Visit the UMB Parking and Transportation Services website for more information.

Jennifer CoolahanBulletin Board, UMB News, University Life, USGANovember 26, 20180 comments
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Beauty break lunch and learns

Lunch & Learns with UM Facial Plastic Surgery

Discover ways to look as young as you feel! Join board-certified physicians from University of Maryland Facial Plastic Surgery & Medical Spa at two upcoming Lunch & Learn sessions as they discuss the latest advances in anti-aging treatment and ways to look your best. Ask the experts and get free samples and treatment discounts. Registration is required and lunch will be served.

Face the Facts: Botox, Fillers, and More

  • Date: Wednesday, Nov. 28
  • Time: Noon-1 p.m.
  • Site: Health Sciences and Human Services Library, fifth floor, Gladhill Board Room

Latest Laser Treatments for Smooth, Glowing Skin

  • Date: Friday, Dec. 7
  • Time: Noon-1 p.m.
  • Site: SMC Campus Center, second floor, Elm Room A
Merideth MarrBulletin Board, Clinical Care, People, University LifeNovember 26, 20180 comments
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UMB Craft Fair: Nov. 30

Don’t Forget: UMB Annual Holiday Craft Fair Set for Nov. 30

Support fellow UMB students, staff, faculty, and other vendors at UMB’s 11th Annual Holiday Craft Fair. Shop early for great holiday gifts, including unique handmade items you can’t find anywhere else!

The fair will be held Friday, Nov. 30, 2018, 11 a.m. to 2:30 p.m., at the SMC Campus Center, Second Floor, 621 W. Lombard St.

Read about last year’s fair.

Alice PowellBulletin Board, University LifeNovember 21, 20180 comments
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Photographer, writer and artist

Students Needed for UMB Art and Literary Journal Editorial Review Teams

UMB’s new art and literary journal, 1807, needs students to join the editorial review team. Help choose which entries are selected for publication! Choose a team to participate on:

  • Visual arts (painting, drawing, photography)
  • Photography
  • Writing (short story, essay, poetry)
  • Other art mediums (sculpture, clay, metal, glass, wood)

Please note that if you’re picked to join a review team, you may not submit an entry to that category, but you may submit to other categories.

Please email Dana Rampolla by Nov. 27 if you’re interested.

 

Dana RampollaBulletin Board, Contests, People, UMB News, University Life, USGANovember 16, 20180 comments
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The President's Message-November

The President’s Message

Check out the November issue of The President’s Message. It includes:

  • Dr. Perman’s column on UMB leadership’s 10-day trip to Asia
  • A look back at Founders Week
  • UMB Police launch COAST outreach team
  • A new cohort of CURE Scholars dons white coats
  • First piece of public art at UMB unveiled
  • Then-Baltimore Police spokesman T.J. Smith joins White Paper discussion on gun violence
  • A look ahead to the UMB TEDx event (Nov. 9) and Barbara Mikulski’s visit (Nov. 27)
  • A roundup of student, faculty, and staff achievements and a call for Board of Regents’ Staff Award nominations
Chris ZangABAE, Bulletin Board, Clinical Care, Collaboration, Community Service, Contests, Education, For B'more, People, Research, UMB News, University Life, USGANovember 9, 20180 comments
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University of Maryland School of Medicine and Center for Vaccine Development and Global Health logo

25th Annual Frontiers in Vaccinology Lecture Set for Nov. 27

Dr. Kathryn M. EdwardsThe Center for Vaccine Development and Global Health (CVD) at the School of Medicine is hosting its 25th Annual Frontiers in Vaccinology guest lecture on Tuesday, Nov. 27, 1 p.m. to 3 p.m., at MSTF Leadership Hall.

The speaker is Kathryn M. Edwards, MD, the Sarah H. Sell and Cornelius Vanderbilt Professor of Pediatrics at Vanderbilt University School of Medicine. Edwards’ topic is “Influenza 1918-2018: How Far We’ve Come and Where We Need to Go.”

Edwards joined the Vanderbilt Vaccine Research Program in 1980 and has conducted many pivotal vaccine studies over her career. She has had an extensive experience leading National Institutes of Health-funded, multi-center initiatives; designing, conducting, and analyzing pivotal Phase I, II, and III clinical studies on vaccines and therapeutics; facilitating networking with basic and clinical investigators with a wide range of interests and expertise; and mentoring many of the young investigators who work within the research unit.

For the past decade, Edwards also has led the Centers for Disease Control and Prevention (CDC)-funded Clinical Immunization Safety Assessment site at Vanderbilt, where she and her colleagues assess adverse events associated with vaccines in subjects of all ages. Edwards also was awarded a CDC contract in 2011 to conduct comprehensive pneumonia surveillance studies in more than 2,000 adults and children admitted to Vanderbilt adult and pediatric hospitals and at another community hospital in Nashville, Tenn.

A reception will follow the lecture in the MSTF Atrium.

Joanne MorrisonBulletin Board, EducationNovember 8, 20180 comments
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Don't Block the Box logo

Note to Drivers in the City: Don’t Block the Box

Did you know it’s illegal to block the box in an intersection? Avoid blocking the box — wait to enter an intersection until you are sure you can make it all the way through the intersection. Wait behind the stop bar, not in the crosswalk. Wait behind the stop bar, not in the crosswalk, and look to see if the vehicles in front of you on the other side of the intersection have left enough room for you to make it through without stopping in the crosswalk on the other side.

The fine for a vehicle obstructing or impeding the free flow of traffic in an intersection or marked crosswalk is $125. Learn more at this Baltimore City Department of Transportation webpage.

Dana RampollaBulletin Board, For B'moreNovember 5, 20180 comments
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American Indian Heritage Month

Celebrating American Indian Heritage Month

American Indian Heritage Month began as a one-day celebration in Rochester, N.Y.  In 1915, the Congress of the American Indian Association issued a proclamation declaring the second Saturday in May as American Indian Day. American Indian Day was observed in several states on varying dates, and it was not until 1990 that November was approved as national American Indian Heritage Month by President George H.W. Bush.

Learn more about diversity awareness at UMB.

Dana RampollaBulletin Board, Global & Community Engagement, University LifeNovember 5, 20180 comments
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School of Social Work logo

Alliance of Anti-Racist Social Work Practitioners to Meet on Nov. 16

The first meeting of the Alliance of Anti-Racist Social Work Practitioners will take place on Friday, Nov. 16, at 12:15 p.m. in Room 2W11 of the School of Social Work at 525 W. Redwood St.

Social workers, other students, and Baltimore community members are welcome to join us.

Come hungry! There will be sticky wings, salad, drinks, and cake, provided by Breaking Bread LLC.

The Alliance is a student-led community organization dedicated to racial justice.

For more information and questions, email Katie Golden or follow the group on Facebook.

Kaitlyn GoldenBulletin Board, Community Service, Education, For B'more, Research, University Life, USGANovember 2, 20180 comments
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