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Latest Issue of ‘Connective Issues’ Newsletter is Online

The December 2017 issue of the Connective Issues newsletter from the Health Sciences and Human Services Library (HS/HSL) is now available.

The topics in this issue include:

  • Why All the Kerfuffle About ResearchGate and SciHub?
  • HS/HSL Partners With the NIH All of Us Research Program
  • 3D-Print Your Holiday Ornaments!
  • HS/HSL Cancels Web of Science
  • Graphic Medicine Collection
  • Collection Realignment Process
  • Bioinformatics and Data Science Workstation
  • HS/HSL Maker Expo – March 6, 2018 – Save the Date!
  • UMB Entrepreneur Toolkit
  • Library Genie 2017 Survey Results
  • Collaborative Learning Room Now Available!
  • Gender Neutral Bathroom
  • “Unmasking the Trauma of War” Luncheon and Guest Speaker
Everly Brown Collaboration, Community Service, Education, People, Research, Technology, University LifeDecember 5, 20170 comments
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HS/HSL NIH Lectures

HS/HSL Hosts NIH Virtual Lectures on Data Science

Network with researchers and librarians at HS/HSL as we live stream the latest event in the NIH’s Guide to the Fundamentals of Data Science lecture series.

The lectures will cover the basics of data management, representation, computation, statistical inference, data modeling, and other topics relevant to “big data” biomedicine.

The series will provide essential training suitable for individuals at all levels of the biomedical community.

Lecture Schedule

Fridays through Dec. 16
Noon to 1 p.m.
Health Sciences/Human Services Library, Distance Education Room

  • Friday, Sept. 16 – Data Management Overview (Bill Hersh, Oregon Health Sciences)
  • Friday, Sept. 23 – Finding and Accessing Datasets, Indexing, and Identifiers (Lucila Ohno-Machado, UCSD)
  • Friday, Sept. 30 – Data Curation and Version Control (Pascale Gaudet, Swiss Institute of Bioinformatics)
  • Friday, Oct. 7 – Ontologies (Michel Dumontier, Stanford)
  • Friday, Oct. 14 – Metadata Standards (Zachary Ives, Penn)
  • Friday, Oct. 21 – Provenance (Suzanne Sansone, Oxford)
  • Friday, Oct. 28 – Data Representation Overview (Anita Bandrowski, UCSD)
  • Friday, Nov. 4 – Databases and Data Warehouses, Data: Structures, Types, Integrations (Chaitan Baru, NSF)
  • Friday, Nov. 11 – No lecture, Veteran’s Day
  • Friday, Nov. 18 – Social Networking Data (TBD)
  • Friday, Nov. 25 – No lecture, Thanksgiving
  • Friday, Dec. 2 – Data Wrangling, Normalization, Preprocessing (Joseph Picone, Temple)
  • Friday, Dec. 9 – Exploratory Data Analysis (Brian Caffo, Johns Hopkins)
  • Friday, Dec. 16 – Natural Language Processing (Noemie Elhadad, Columbia)
Brian ZelipBulletin Board, Collaboration, Education, People, Research, TechnologySeptember 12, 20160 comments
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HS/HSL Named Regional Medical Library

The Health Sciences and Human Services Library (HS/HSL) has been awarded a cooperative agreement to continue in this capacity from 2016-2021. This agreement, worth over $6M, supports the National Institutes of Health’s (NIH) National Library of Medicine health information outreach efforts over 10 southeastern states, Puerto Rico, U.S. Virgin Islands, and the District of Columbia, representing 25 percent of the U.S population.

Additionally, HS/HSL has been named the National DOCLINE Coordinating Office to facilitate resources sharing across the United States. Learn more about the award.

Everly BrownEducation, Research, UMB NewsApril 4, 20160 comments
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Barney Graham

22nd Annual Frontiers in Vaccinology Lectureship

The Center for Vaccine Development at the University of Maryland School of Medicine welcomes Barney S. Graham, MD, PhD, deputy director, Vaccine Research Center, NIAID, NIH, and chief, Viral Pathogenesis Laboratory and Translational Science Core, as this year’s Frontiers in Vaccinology Visiting Professor and presenter.

The lecture takes place on Nov. 17, 2015 at 1p.m. in the Medical School Teaching Facility (MSTF) auditorium.

Dr. Graham will present “Next Generation Vaccines: The New Paradigm of Atomic Level Design.” The lecture is open to all faculty, staff, and students interested in the topic. A reception follows.

Dottie Small Bulletin Board, Education, People, Research, University LifeOctober 16, 20150 comments
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Regional Medical Libraries Make a Difference

Stretching from the nation’s capital and adjacent Maryland and Virginia before dropping down along the Gulf Coast and into the deep south, and reaching over to the U.S. Virgin Islands and Puerto Rico, the Southeastern/Atlantic (SE/A) Region is a rich mosaic of urban, rural, and remote areas.

Headquartered in Baltimore at the University of Maryland Health Sciences and Human Services Library (HS/HSL), the SE/A Region supports collaboration among 34 resource libraries and more than 1,000 network members, including hospital libraries and community-based organizations, located across Alabama, the District of Columbia, Florida, Georgia, Maryland, Mississippi, North Carolina, Puerto Rico, South Carolina, Tennessee, Virginia, the U.S. Virgin Islands, and West Virginia. The region includes three of the 10 wealthiest states or federal districts (DC, Maryland, and Virginia), as well as four of the poorest (Alabama, Mississippi, South Carolina, and West Virginia).

NLM in Focus spoke recently with SE/A Director M.J. Tooey and Executive Director J. Dale Prince.

NLM in Focus: What makes your region unique and interesting?

We serve a huge geographic area with a fourth of the country’s people and some of its busiest, most populous cities, as well as remote rural areas, particularly in Appalachia and West Virginia. Our region contains important information and research centers, including the Library of Congress, the Centers for Disease Control and Prevention (CDC), and the NLM.

Ours is a real mix, from federal agencies and world-class medical centers like the NIH to many special and underserved populations. Our region includes a large black population and is home to 72 percent of the Historically Black Colleges and Universities. The Asian and Hispanic populations are growing, along with Cuban Americans and Haitians in Florida, Puerto Ricans, and residents of the U.S. Virgin Islands. Each group has its own customs, culture, and sometimes language that we need to accommodate and understand. The region is full of contrasts.

NLM in Focus: Are there challenges specific to your region? If so, how have you overcome them?

We rely on a decentralized approach for delivering programs. The region is simply too large to approach our mission any other way. Most staff work out of our Baltimore headquarters, but we rely on our network members in each state to take the initiative and do the bulk of the outreach. They propose and monitor programs and stay connected. We assign a coordinator to each state or region to oversee projects and programs.

Our coordinators travel extensively to meet with people in their states or regions. We know them and understand their needs. Personal connections are so important for maintaining a robust health information outreach effort such as ours.

NLM in Focus: What are your proudest accomplishments?

Helping underserved military families. In recent years, we funded the Military Partners and Family Coalition (MPFC), an organization supporting lesbian, gay, bisexual, transgender and similarly identified (LGBT) military families.

We got involved when we realized that many military families are “hidden” and consequently underserved. We worked to obtain MPFC and NN/LM funding, and then reached out to those families, gathered baseline data on their physical and mental health needs and whether they were being met, and produced the MPFC Community Health Care Study Report 2011-2012.

That in turn led us to a partnership with the National Association of Social Workers (NASW), which helped ensure the report’s use by social workers serving the military and veterans community. The MPFC results are now part of a larger, on-going military-wide study started in 2014 by the Naval Center for Combat & Operational Stress Control and researchers from Palo Alto University. The study will assess sexual minority stress and changes in perceived stigma in the wake of “Don’t Ask, Don’t Tell.”

We also are extremely proud to have helped support Marilyn Lance-Robb, founder/owner of MaFlo’s Health & Awareness Team/MaFlo’s Beauty Salon, and her work in Georgetown, SC. She is using computers with Wi-Fi internet access at MaFlo’s as part of an innovative program to bring health information to her customers.

In Parrottsville, TN, we support Karin Hoffman, the Director of the Migrant Health Program for Rural Medical Services, Inc. (RMS), which operates several primary care clinics in the state. Three of the RMS clinics have bilingual staff capable of serving Spanish speakers, and they provide outreach to the Hispanic population with home visits, emergency follow-up, outreach clinics at farm worker labor camps and housing areas, and health education.

We’re pleased with our program that pays the processing fees of many MLA Consumer Health Information Specializations and Disaster Information Specializations. We now are piloting a project in Maryland and West Virginia to provide free registration to any public librarian who wishes to acquire either or both of these specializations.

Our most important accomplishment, and one at which we are constantly working, is maintaining our quality standing in the eyes of our network members. Based upon Mid-Contract Review surveys of our network base and discussions with representative groups of members who dealt with us recently, either through funding or classes, we have maintained those important relationships. Although the new contract format was challenging to work with given our outreach needs, our members remain appreciative.

NLM in Focus: How has technology impacted your work?

Technology is always a challenge because there is always something new. We stay alert and scramble to keep up. For outreach though, we wouldn’t be where we are without technology. We use Adobe Connect for daily, weekly, and monthly meetings. Technology allows us to connect and serve our populations almost instantly. Members of the RML staff are accessible all of the time via Skype, text messages, and email. We use Facebook, Twitter, and our own blogs to spread the word or update our remote sites. Our SEA Currents newsletter blog is very popular.

We Skype a lot for remote, face-to-face meetings and we still fax occasionally. Accessibility is a serious issue, not just in remote regions but in cities, too. Some users can’t or won’t use technology; some still don’t have access to the Internet or mobile devices.

Verma Walker stands next to and gestures toward a 3-D printer on a nearby table.

NLM in Focus: Tell us about your recent community outreach projects.

What we do best is “build capacity.” That is, through our network, our educational outreach, and our funding, we enable network members to perform more and better outreach. We are proud of the way our network members are able to take our offerings and do wonderful things with them.

Our goal is to develop partnerships within the region. And when you speak of partnerships, we have a great variety. We already mentioned Marilyn Lance-Robb and Karin Hoffman, but we also support people like Rick Wallace, who received the 2013 Michael E. DeBakey Library Services Outreach Award from the Friends of the National Library of Medicine. He has devoted his life to serving rural and underserved populations. Rick’s project, “A Simple Plan,” provided instruction for public librarians across the 500-mile width of Tennessee. His team traveled thousands of miles over a 6-year period, performing outreach to roughly 1,000 people and helped 250 receive the MLA Consumer Health Information Specialization. He also works with 20 rural hospitals, 20 rural clinics, and many public health departments to provide remote library access. Additionally, he’s gone on to target specific consumer health populations. He says that none of this would be possible without NN/LM.

We provide training and professional development opportunities to those who directly provide health information to the public, including network and other librarians, health professionals (including public health professionals), educators, health advocates, and those working with various community-based organizations. Part of that effort involves helping people understand the Affordable Care Act, its benefits, and how to apply and obtain primary care and preventive services.

NLM in Focus: Any further thoughts about your region and the work you do?

It is always about the people, always about making it easier for people to access quality health information. People in the region know our staff. We are not some distant entity. We try to connect, to understand their needs and ask them, “How can we help?” There always is a need for good programs and health information, and that’s what drives us.

We meet new people and hear new ideas. We forge relationships and, together, we make a difference.

Photo caption: Southeastern/Atlantic Region Executive Director Dale Prince and Communications Coordinator Tony Nguyen promote NLM resources at a conference.

Julia PellegriniCollaboration, Education, Global & Community Engagement, People, Research, TechnologyJuly 13, 20150 comments
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Perman and Hrabowski at Symposium

Catalyst for Collaboration

Celebrating the rapid growth of our collaborative research programs, UMBC and the University of Maryland, Baltimore (UMB) joined together for an inaugural Research & Innovation Partnership Symposium on Friday, Jan. 30.

The Value of Collaborative Research

UMB-UMBC Research Symposium

UMB-UMBC Research Symposium (All photos courtesy of Marlayna Demond for UMBC)

UMBC President Freeman Hrabowski and UMB President Jay Perman greeted a standing-room only audience of faculty researchers, students, and research support staff, and reflected on the value of collaborative research for both institutions. Yvonne Maddox, acting director of the NIH Institute on Minority Health and Health Disparities (NIMHD), delivered a keynote address focusing on the need to expand research on health disparities and how our institutions can support diverse young researchers entering this field. Scientific talks presented by collaborative research teams who received UMBC-UMB Partnership Grants in 2013 and an interactive poster session rounded out the symposium agenda.

“We are thrilled about the positive response by our campus communities to this inaugural research symposium,” stated Karl V. Steiner, UMBC’s vice president for research. “It serves as an important milestone for us to take stock of how far we have come with our relationship, but to also recognize how much more work and opportunities still lay ahead.”

UMBC-UMB Research & Innovation Partnership Seed Grant Program

The UMBC-UMB Research & Innovation Partnership Seed Grant program seeks to establish, enhance, and promote interinstitutional research collaborations between the two USM institutions and to stimulate joint grant proposals to federal agencies and foundations. USM Chancellor William E. Kirwan has praised the program for its “focus on cutting-edge science and health concerns” and its emphasis on interdisciplinary teamwork. The grant program is now in its second year, and the symposium offered an exciting stage to announce a new group of grant recipients.

Collaboration at the Symposium

Collaboration at the Symposium

This year’s grant program consists of two tracks — Innovation Seed Grants of up to $50,000 and Innovation Challenge Grants for senior researchers for up to $75,000 per year for two years. The committee received 21 applications — nine for the innovation seed track and 12 for the innovation challenge track — and awarded funding to four teams of three researchers each.

Grant Recipients

Innovation Seed Grant recipients include the team of Ronghui Ma and Liang Zhu (UMBC, mechanical engineering) and Hongbing Wang (UMB School of Pharmacy), and the team of Nirmala Roy and Aryya Gangopadhyay (UMBC, information systems) and Elizabeth Galik (UMB School of Nursing).

Innovation Challenge Grant recipients include the team of Raimi Quiton (UMBC, psychology), Radi Masri, and David Seminowics (UMB School of Dentistry); and the team of Zeev Rosenzweig (UMBC, chemistry and biochemistry), Toni Antalis, and Rajabrata Sarkar (UMB School of Medicine).

Ronghui Ma, associate professor in mechanical engineering, is working with her colleagues to create a 3-D-printed chip that will allow scientists to test drugs on cells from different organs at the same time. She says that with this work, made possible by the grant program, the team can provide a new model for drug testing.

Zeev Rosenzweig, chair and professor of chemistry and biochemistry, and his UMB colleagues are working to develop a new method to prevent or delay amputation in diabetes patients. He explains that his goal is to prepare an NIH proposal using the preliminary data obtained during the next two years of research. “Without this funding mechanism,” Rosenzweig shares, “this collaboration wouldn’t happen.”

Previous seed grant recipients, reflecting on a year of collaboration across institutions, share this view. The inaugural program received 42 collaborative proposals in the summer of 2013, and awarded five teams 12-month grants of $75,000 each:

• Kathleen Hoffman (UMBC, mathematics and statistics) and Asaf Keller (UMB School of Medicine)

• Tülay Adali (UMBC, CSEE) and Kelly Westlake (UMB School of Medicine)

• Charles Bieberich (UMBC, biological sciences) and Paul Shapiro (UMB School of Pharmacy)

• Marie-Christine Daniel (UMBC, chemistry and biochemistry) and Peter Swaan (UMB School of Pharmacy)

• Bradford Peercy (UMBC, mathematics and statistics) and Martin Schneider (UMB School of Medicine)

The Impact of Grants

The grant recipients describe the program as having a dramatic impact on their work. “This program helped me start a whole new collaboration,” says Kathleen Hoffman, professor of mathematics and statistics.

Charles Bieberich, professor of biological sciences, agrees. “Having a pool of money that I could apply for made me stop and think about whom at UMB I could reach out to and establish a collaboration,” he says. “The funding acts as a catalyst to move the work forward.”

The UMBC-UMB Partnership Grants program is supported by the Office of the Provost and Office of the Vice President for Research at UMBC, and by the deans of the UMB schools of medicine, pharmacy, nursing, and dentistry.

Story courtesy of UMBC.

Dinah WinnickCollaboration, Education, For B'more, People, Research, UMB NewsFebruary 18, 20150 comments
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Saving Lives Worldwide

Angela Brodie is a fourth-generation scientist. But to say she’s gone into the family business is a bit of an understatement: Brodie, PhD, professor of pharmacology at the University of Maryland School of Medicine (SOM), is one of the world’s most decorated scientists in cancer research. Her pioneering work over 40 years has saved the lives of thousands of women worldwide.

Early in her career, Brodie won a National Institutes of Health (NIH)-sponsored fellowship to the Worcester (Mass.) Foundation for Experimental Biology. It was at the foundation that she met her husband; together, they began developing inhibitors to block estrogen synthesis. Brodie was confident this could be the link leading to non-surgical breast cancer treatment. The proposal she submitted to NIH hypothesizing as much was funded by the agency in 1975. Four years later, she relocated her laboratory to the SOM.

Her research over the next 20 years laid the groundwork for a class of drugs called aromatase inhibitors, which help prevent recurrence of breast cancer in postmenopausal women by reducing estrogen produced by the body, thereby starving the hormone-dependent cancer cells.

Prior to her discovery, the primary non-surgical breast cancer treatment was tamoxifen, a drug that, despite its effectiveness, can lead to stroke and endometrial cancer. Today, aromatase inhibitors, which are effective without incurring serious complications, have supplanted tamoxifen as the go-to defense against breast cancer, diagnosed in nearly a quarter-million American women each year. “The development of this class of drugs is arguably one of the most important therapeutic advances in treating women with breast cancer in the last quarter century,” says Kevin Cullen, MD, director of the University of Maryland Marlene and Stewart Greenebaum Cancer Center.

Brodie has been funded by the NIH for four decades, and is the first woman to be awarded the prestigious Kettering Prize from the General Motors Cancer Research Foundation. Among many additional awards, she’s won the Susan G. Komen Breast Cancer Foundation’s International Brinker Award, the Landon Award from the American Association of Cancer Research, and the Pharmacia Award of the American Society for Experimental Therapy. In 2013, she was in the first class of fellows inducted into the American Association for Cancer Research Academy, established to honor scientists whose major scientific contributions have catalyzed significant progress against cancer.

Following her breakthrough in breast cancer research, Brodie began developing inhibitors against prostate cancer, which had claimed her father. She believed the mechanisms leading aromatase inhibitors to suppress the disease in the breast might apply equally well to cancer of the prostate.

Brodie collaborated with the SOM’s Vincent Njar, PhD, and together they developed a promising compound, VN/124. The compound is the basis for galeterone, an androgen-blocking drug Brodie and Njar have exclusively licensed to Tokai Pharmaceuticals. Results of Phase 2 clinical trials, recently concluded, are extremely encouraging: Trial subjects’ prostate-specific androgen (PSA) levels, often elevated in men with prostate cancer, are significantly reduced, and galeterone’s approval has been fast-tracked by the Food and Drug Administration.

Brodie’s great-grandfather, grandfather, and father were all accomplished scientists before her. And while it’s tempting to say that she’s followed in their footsteps, it’s clear the path she’s paved is all her own.

Mike RuddockClinical Care, Education, People, ResearchSeptember 26, 20140 comments
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Can Breathing Problems Cause Diabetes?

Could Short-Term Breathing Problems Contribute to Diabetes?

The National Institutes of Health (NIH) estimates that, by the year 2030, 30 million Americans will suffer from diabetes. Preventing this disease from reaching epidemic proportions will require clinicians to rethink conventional diagnosis and treatment methods, according to Eung-Kwon Pae, DDS, PhD, MSc, chair of the School of Dentistry’s Department of Orthodontics and Pediatric Dentistry.

Pae recently published research that shows how a breathing problem that affects infants could contribute to the development of diabetes later in life. His paper, “Insulin Production Hampered by Intermittent Hypoxia via Impaired Zinc Homeostasis,” was published in the February edition of the journal PLOS One.

Intermittent Hypoxia

Eung-Kwon Pae

Eung-Kwon Pae

Pae’s research focuses on a condition known as intermittent hypoxia, which is a short-term breathing difficulty that some infants and preterm babies experience right after birth. “As long as the baby survives that early period, doctors tend to disregard the breathing problem the baby had when he or she was born,” says Pae.

His research shows that a few intermittent hypoxic events can affect the insulin-producing cells in the pancreas. The hypoxic breathing condition, even if it only lasts for a few minutes, can destroy molecular transporters (known as ZIP8 transporters) that allow the mineral zinc to be absorbed into these pancreatic cells.

Without zinc, the cells are unable to produce insulin. If a patient’s ZIP8 transporters have been destroyed, even if the patient is given zinc supplements, pancreatic cells will still be unable to produce insulin. “My challenge now is to find a way to boost a patient’s ZIP8 level,” remarks Pae.

Adult Onset of Type 1 Diabetes

Pae’s research could also explain why more and more older adults are being diagnosed with Type 1 diabetes, which is a condition that is typically diagnosed during childhood. “Once the damage is done to these ZIP8 transporters, that damage lasts for the patient’s entire life. If a diabetic condition occurs, doctors must address it right away. The condition will only get worse as the child gets older,” Pae states.

He plans to conduct additional studies to determine the mechanism that destroys ZIP8 transporters during intermittent hypoxia. Pae hopes this research could help clinicians repair the damage and, possibly, reverse a patient’s diabetic condition.

Adam ZewePeople, Research, UMB NewsMarch 21, 20140 comments
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America’s #1 Program in Health Law

The Francis King Carey School of Law’s pioneering program in health law focuses on training students and supporting research in health-related legal and policy issues including health care reform, disability law, the legal and ethical questions surrounding the emerging field of genetics and personalized medicine, and racial and ethnic disparities in access to health care.

“The Law and Health Care Program’s number one ranking recognizes the wide-reaching and interprofessional approach to teaching health law that is critical in today’s evolving health care environment,” said President Jay A. Perman, MD.

Interdisciplinary & Interprofessional Education

The program’s emphasis on interdisciplinary and interprofessional education involves faculty and students from the School of Law, as well as the University’s schools of medicine, pharmacy, dentistry, nursing, and social work who collaborate on initiatives ranging from health and human rights to food and drug law.

“Health law is a very broad area,” said Diane Hoffmann, MS, JD, director of the law and health care program, and professor of law. “We have health law courses on the business of health care, such as fraud and abuse, and hospital law, as well as courses in public health law, HIV and AIDS law, bioethics, and food and drug law and policy.”

Interdisciplinary events and initiatives are a major focus of the law and health care program. Recently, the program held a Health Law and Regulatory Science Competition that challenged students to come up with innovative new ideas on topics such as Food and Drug Administration regulations of drugs and medical devices, health care fraud issues, and compliance with National Institutes of Health and FDA ethical research requirements.

Program History

Since its inception in 1997, more than 350 students have graduated with a law degree and a concentration in health law, recognizing their completion of at least 17 credits in health law through classroom, experiential learning, and research and writing courses.

“I am delighted that faculty at law schools across the country have recognized the high caliber of our law and health care program. But I’m not surprised,” said Phoebe Haddon, JD, LLM and dean of law school. “The work of our faculty and students is not only original, but practical. It’s improving the lives of people touched by an increasingly complicated health care system every day.”

Opportunities for Students

“We have lots of externship opportunities at state and federal agencies as well as hospitals in Baltimore, and Washington, D.C.,” Hoffmann said. “And we have students who do externships at U.N. AIDS in Geneva, and who have been placed at the World Health Organization’s Office of Human Rights.”

The Journal of Health Care Law & Policy, which is part of the law and health care program, also offers students the opportunity to acquire experience in research, writing, and editing. Launched in 1998 as one of the few scholarly journals to bridge the legal, public policy, and scientific fields, it is published twice yearly and covers a range of topics including the legal and public health challenges of substance abuse, the legacy of tobacco litigation and the legal and regulatory obstacles to vaccine development.

Students who choose to earn their Health Law Certificate have access to externship opportunities to work with nonprofit and governmental agencies dealing with health law issues, providing them with practical experience working in the field.

Grants From NIH

Faculty within the program work with researchers at other schools on the campus on emerging topics in medicine, science, and law. A grant from the National Institutes of Health’s Human Microbiome Project supports research on federal regulation of probiotics, with Hoffmann as a co-principal investigator in conjunction with research scientists at the Institute for Genome Sciences at the School of Medicine.

The project was supported by a three-year grant from the National Institutes of Health as part of the ethical legal and social implications component of the Human Microbiome Project.

Faculty within the program are also examining regulation of genetic testing, human subjects research, pain management, HIV/AIDS law, and much more. The scholarly work of the law and health care program is used in policy-making on both the federal and state levels.

Jill YeskoCollaboration, Education, For B'more, UMB NewsMarch 12, 20140 comments
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