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In this interview on "The External Medicine Podcast," Mitch Belkin (UMSOM) and Daniel Belkin (Albert Einstein College of Medicine) speak with Stephan Guyenet, PhD, about Glucagon-like peptide-1 (GLP-1) and Semaglutide. They discuss GLP-1’s mechanisms of action, experiments on food reinforcement, and nutrient receptors in the small intestines. Finally, they touch on some exciting new weight loss drugs that may replace Semaglutide and potentially even bariatric surgery.

Who is Dr. Stephan Guyenet?

Stephan Guyenet received his PhD in neurobiology and behavior from the University of Washington. Afterward, he completed a postdoctoral fellowship in the neuroscience of obesity. He is the author of the book The Hungry Brain. Guyenet is the founder and director of Red Pen Reviews, which publishes expert reviews of popular nutrition books with structured semi-quantitative evaluations. In addition, he is a senior researcher at GiveWell, where he conducts cost effectiveness analyses on water-quality interventions and malnutrition treatments in low-income countries.

"The External Medicine Podcast" explores nontraditional ideas and innovation through longform interviews. Co-hosts Mitch Belkin and Daniel Belkin are medical students and brothers with diverse interests. Mitch, a former Fulbright scholar, and Daniel, a former filmmaker, examine new ideas and innovation on the outskirts of medicine.

Available on Spotify, Apple Podcasts, and Google Podcasts.

Follow us on twitter @ExMedPod.


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