Two wooden silhouettes of heads on a blue background, one filled with colorful paper balls, the other with black ones, symbolizing contrasting thoughts.

How one simple question can interrupt stress and shift your thinking. Part of the “Wellness Matters” blog series.


What happens in your body when you imagine getting a message from your boss that says, “Can we talk?” 

If you’re like me, when I received that exact text last week, your heart might race, your breathing quickens, and your palms start to sweat. My thoughts spiraled from, “Well, this could be concerning” to “I’m going to lose my job.”  

I called him back immediately. 

The good news? My boss wasn’t upset. He just needed a quick answer to a simple question and hadn’t thought twice about the wording. Within minutes, my body settled down — and I even laughed at how quickly my mind had created a worst-case scenario. 

Why Do Our Minds Jump to the Worst-Case Scenario? 

As a clinical psychologist trained in cognitive behavioral therapy (CBT), I’m reminded daily that our thoughts influence our emotions, physiology, and behavior. Every thought sparks a cascade of neurochemicals and hormones. Stressful thoughts raise cortisol, while reassuring thoughts release serotonin and oxytocin.  

Our brains have evolved to detect danger, so they tend to overreact to uncertainty. That’s why an ambiguous text message, tone, or look can trigger the same physiological stress response as a genuine threat. 

How Thoughts Affect the Body 

When worry becomes a habit, it keeps your body in a near-constant state of tension and inflammation. Imagine enough worst-case scenarios and your body reacts as if they’re happening right now.  

That text message from my boss? My body reacted as though I’d already lost my job, even though the “threat” was only in my head.  

The bottom line: Your body takes your thoughts seriously, and your body responds accordingly.  

Can You Really Rewire Stressful Thinking? 

Here’s the good news: Just as negative thoughts wire us for stress, hopeful thoughts restore balance and resilience.  

CBT research consistently shows that intentionally shifting thought patterns can improve mood, reduce anxiety, and even support physical health. The best part? It only takes a few minutes for the body to return to equilibrium once the brain receives a signal of safety. 

Try This: Positive “What If’ing” 

Instead of spiraling into “What if this goes wrong?” try flipping the script. Ask yourself: 

  • What if this works out better than I expected? 
  • What if tomorrow is a little bit easier? 
  • What if I’m more capable than I think? 
  • What if I learn something valuable through this? 

The brain treats questions as open loops, automatically searching for answers. By asking more constructive questions, you guide your mind toward curiosity and calm instead of fear and tension. 

Wait, Isn't This Toxic Positivity? 

Toxic positivity is the pressure to stay upbeat or “look on the bright side” no matter what you’re feeling. Positive “what if’ing” works because it does the opposite. Instead of forcing optimism or ignoring difficult emotions, asking “what if” acknowledges stress and uncertainty while giving your brain a different perspective. 

When you ask, “What if this turns out OK?” you’re not pretending everything is fine, you’re helping your brain consider another realistic possibility. That shift reduces tension without dismissing what’s real. 

Try It: Own Your Positive "What If" 

Take a moment right now to craft your own positive “what if.” 

Notice how your body responds. The shift feels subtle but over time this exercise retrains your brain to expect safety and possibility instead of a threat.  

If you practice positive “what if’ing” consistently, you’ll start to notice your stress responses settling more quickly, even in moments of uncertainty.  

The Takeaway 

By changing the question, you change your chemistry. And when your chemistry changes, so does your experience.  

So, where in your life today can you flip a thought with a positive “what if”? Remember, your body is always listening. Speak wisely. 


This article is part of “Wellness Matters,” a blog series created to explore health and wellness issues and share evidence-based tools you can use to strengthen your well-being.

Found it helpful? Subscribe to the “Wellness Matters” newsletter to receive new posts directly in your inbox. Get monthly insights leading up to the webinar, “An Integrative Approach to Stress Management: Practical Tools for Building Resilience and Well-Being,” on April 21, 2026.


About the Author  

Michelle Pearce, PhD, is professor and director of the Integrative Health and Wellness certificate program at the University of Maryland School of Graduate Studies. 

Dr. Pearce is a clinical psychologist who researches the relationship between religion/spirituality, coping, and health, as well as the integration of spirituality into the practice of psychotherapy. Her areas of clinical expertise include cognitive behavioral therapy, mind-body stress reduction methods, existential issues, and behavioral medicine to address the intersection of mental and physical illness. Read her full biography.

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