The University of Maryland is conducting a research study that will look at whether calcium, vasopressin, or both early in the course of treatment would help severely injured patients who lose a lot of blood survive their injuries.
The CAlcium and VAsopressin following Injury Early Resuscitation (CAVALIER) trial will include approximately 1,050 people ages 18 to 90. Patients who have traumatic injuries with loss of blood may be enrolled by participating emergency medical personnel during their transportation to the hospital or after arrival to a participating hospital.
CAVALIER is an Exception from Informed Consent (EFIC) trial, meaning that, the trial requires performing a potentially lifesaving intervention in people who are too injured to give permission. This study will look at treatment for patients who have a traumatic injury and have lost a lot of blood. These patients are too injured to give permission before receiving the study drug. Permission for continued participation will be obtained from patients once they are able, or from their family members, as soon as possible.
For more information about CAVALIER or to complete an anonymous survey on your thoughts about this EFIC study, please go to www.litesnetwork.org/CAVALIER.
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