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In this interview, Mitch Belkin (University of Maryland School of Medicine) and Daniel Belkin (the Albert Einstein College of Medicine) speak with Dr. Karl Friston about his proposed free energy principle and how it applies to various psychiatric and neurological disorders including schizophrenia, depression, autism, and Parkinson’s. They also touch on the disconnection hypothesis of schizophrenia, how theories of schizophrenia have evolved over the last two centuries, and the relationship between schizophrenia and autism.

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Who is Karl Friston?

Dr. Karl Friston is a professor of neuroscience at University College London and an authority on brain imaging. He is the 20th most-cited living scientist with over 260,000 citations for his works. After studying natural sciences at Cambridge, he completed his medical studies at King’s College Hospital in London and worked for two years in an inpatient psychiatric facility on the outskirts of Oxford, where he treated patients suffering from schizophrenia.

Friston has developed a number of statistical tools for analyzing data from the brain, including statistical parametric mapping (SPM), voxel-based morphometry (VBM) or dynamic causal modeling (DCM). His mathematical contributions include variational Laplacian procedures and generalized filtering for hierarchical Bayesian model inversion.


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Daniel Belkin and Mitch Belkin are brothers and fourth-year medical students. "The External Medicine Podcast" is a podcast exploring nontraditional medical ideas and innovation. 

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